反应详情

To a solution of 5-isopropoxyquinoline (1.87 g, 10.0 mmol) in acetonitrile (100 mL) was added NBS (1.78 g, 10.0 mmol) at 0° C. The mixture was stirred at rt for 2 h before the solvent was removed. The residue was partitioned between EtOAc and H2O. The layers were separated and the organic layer was washed with brine, dried over MgSO4, and concentrated. The crude material was purified by column chromatography (0-10% EtOAc-Hex) to provide 8-bromo-5-isopropoxy-quinoline (92%) as a light brown solid. ESI-MS m/z calc 265.1, found 266.1 (M+1)+. Retention time: 1.44 minutes (3 min run).

1. customwas removed
2. customThe residue was partitioned between EtOAc and H2O
3. customThe layers were separated
4. washthe organic layer was washed with brine
5. dry with materialdried over MgSO4
6. concentrationconcentrated
7. customThe crude material was purified by column chromatography (0-10% EtOAc-Hex)