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HRID 2204275作成日：2026年10月27日
Isopropyl iodide → (4-ethoxy-2-isopropoxy-phenyl)-(1-methyl-1H-spiro[chromeno[4,3-c]pyrazole-4,4'-piperidine]-1'-yl)methanone
https://huagongshe.com/reaction/2204275
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Isopropyl iodide | HCID 6362 | — |
| 反応物 | Potassium Carbonate | HCID 11430 | — |
| 反応物 | (4-ethoxy-2-hydroxyphenyl)(1-methyl-1H-spiro[chromeno[4,3-c]pyrazole-4,4'-piperidine]-1'-yl)methanone | HCID 58551483 | — |
| 溶媒 | Dimethylformamide | HCID 6228 | — |
| 生成物 | (4-ethoxy-2-isopropoxy-phenyl)-(1-methyl-1H-spiro[chromeno[4,3-c]pyrazole-4,4'-piperidine]-1'-yl)methanone | HCID 58551295 | 36.8% |
反応手順
To a vial containing a solution of (4-ethoxy-2-hydroxyphenyl)(1-methyl-1H-spiro[chromeno[4,3-c]pyrazole-4,4′-piperidine]-1′-yl)methanone (41 mg, 0.1 mmol) in DMF (0.8 mL) was added K2CO3 (69 mg, 0.5 mmol), and 2-iodopropane (15 μL, 0.15 mmol). The mixture was stirred for 3 hours at 25° C. The crude reaction mixture was filtered and purified by HPLC (1-99%) MeOH:H2O to yield (4-ethoxy-2-isopropoxy-phenyl)-(1-methyl-1H-spiro[chromeno[4,3-c]pyrazole-4,4′-piperidine]-1′-yl)methanone (17 mg, 33%). ESI-MS m/z calc. 461.5, found 462.2 (M+1)+. Retention time: 3.16 minutes (4 min run).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| 特許番号 | US09365588B2 |
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| 出典データセット | uspto-grants-2016_06 |
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| ORD ID | ord-3d73bd8a197942a5a7336b1408d32cb2 |
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| 出典メモ | uspto-grants-2016_06 |
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