Potassium Sodium Tartrate → HCID 178456183, compound

Participants

Reaction Conditions

Reaction Steps

A solution of trimethylaluminium (2M in toluene) [75-24-1] (16.75 mmol) was added to a solution of 2-[(4-chloro-phenyl)-(trans-4-hydroxy-cyclohexylamino)-methyl]-1-isopropyl-1H-pyrrole-3-carboxylic acid ethyl ester (Step F2) (5.58 mmol) in toluene (25 mL) and the mixture was stirred at 75° C. for 25 h. The mixture was cooled to rt, poured onto a stirring ice-cold solution of saturated Rochelle's salt and then diluted with EtOAc. The phases were separated. The aqueous layer was extracted with EtOAc (2×). The combined organic layers were washed with brine, dried (Na2SO4) and concentrated. The residue was purified using a RediSep® silica gel column to afford the title compound as a beige solid. tR: 3.99 min (HPLC 1); ESI-MS: tR=0.97 min, [M+H]+ 373/375 (LC-MS 1); TLC: Rf=0.27 (EtOAc).

Provenance & Evidence