5-bromo-2-[(3-chloro-4-fluoro-phenylamino)-(4-chloro-phenyl)-methyl]-1-isopropyl-1H-pyrrole-3-carboxylic acid methyl ester → 5-bromo-2-[(5-chloro-2-methyl-phenylamino)-(4-chloro-phenyl)-methyl]-1-ethyl-1H-pyrrole-3-carboxylic acid

Participants

Reaction Steps

The title compound was prepared in analogy to the procedure described for Step D1 but 5-bromo-2-[(5-chloro-2-methyl-phenylamino)-(4-chloro-phenyl)-methyl]-1-ethyl-1H-pyrrole-3-carboxylic acid ethyl ester (Step K2) was used instead of was used instead of 5-bromo-2-[(3-chloro-4-fluoro-phenylamino)-(4-chloro-phenyl)-methyl]-1-isopropyl-1H-pyrrole-3-carboxylic acid methyl ester to afford the title compound as a colorless oil. tR: 5.97 min (HPLC 4); ESI-MS: tR=1.41 min, [M−H] 479/481/483 (LC-MS 1).

Provenance & Evidence