1-Chloro-N,N-2-trimethylpropenylamine → HCID 86703121, compound

Participants

Reaction Steps

1-Chloro-N,N,2-trimethylpropenylamine [26189-59-3] (2.90 mmol) was added to a solution of 2-[[5-chloro-1-(4-methoxy-benzyl)-6-oxo-1,6-dihydro-pyridin-3-ylamino]-(4-chloro-phenyl)-methyl]-1-isopropyl-1H-pyrrole-3-carboxylic acid (Step O2) (1.943 mmol) in CH2Cl2 (20 mL) at 0° C. After stirring for 2 h, the reaction mixture was diluted with CH2Cl2 and successively washed with a saturated aqueous solution of NaHCO3 and brine, dried (Na2SO4), filtered and concentrated. The residue was purified using a RediSep® silica gel column to afford the title compound as a light brown solid. tR: 6.81 min (HPLC 2); ESI-MS: tR=1.13 min, [M+H]+ 522/524/526 (LC-MS 1); TLC: Rf=0.48 (EtOAc).

Provenance & Evidence