関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | S,S-dimethyl carbonodithioate | HCID 313474 | — |
| 反応物 | 2-Triisopropylsilanyloxy-propane-1,3-diamine | HCID 86703132 | — |
| 溶媒 | Methanol | HCID 887 | — |
| 生成物 | 5-Triisopropylsilanyloxy-tetrahydro-pyrimidin-2-one | HCID 86703131 | — |
反応手順
To a solution of 2-triisopropylsilanyloxy-propane-1,3-diamine (Step P10) (27.8 g, 113 mmol) in MeOH (450 mL) was added S,S-dimethyl carbonodithioate (17.7 mL, 169 mmol) and the mixture was stirred at 60° C. for 20 h. The reaction mixture was concentrated. The residue was purified by flash chromatography(CH2Cl2/MeOH, 100:0→5:1) to afford the title compound. ESI-MS: [M+H]+273.3 (LC-MS 1-flow injection).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US09365576B2 |
|---|
| 出典データセット | uspto-grants-2016_06 |
|---|
| ORD ID | ord-81305d4da4ce403c979021e5597f44da |
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| 出典メモ | uspto-grants-2016_06 |
|---|
