Triethylamine → HCID 86703134, compound

Participants

Reaction Steps

A solution of propylphosphonic anhydride (T3P/PPA) (50% in EtOAc) (7.13 mmol) was added dropwise to a solution of 4-chloro-2-[6-(4-chloro-phenyl)-1-isopropyl-4-oxo-4,6-dihydro-1H-pyrrolo[3,4-b]pyrrol-5-yl]benzamide (Step AB2) (3.10 mmol) and Et3N (3.41 mmol) in EtOAc (25 mL) at 45° C. After 23 h, the reaction mixture was cooled to rt and partitioned between EtOAc and H2O. The organice phase was successively washed with a saturated aqueous solution of NaHCO3, water and brine, dried (Na2SO4), filtered and concentrated. The residue was purified using a RediSep® silica gel column to afford the title compound as a white solid. tR: 4.97 min (HPLC 1); ESI-MS: tR=1.19 min, [M+H]+ 410/412/414 (LC-MS 1); TLC: Rf=0.16 (1:3 EtOAc/heptanes).

Provenance & Evidence