Dimethylalumanylium chloride → 4-{5-[5-Chloro-1-(4-methoxy-benzyl)-6-oxo-1,6-dihydro-pyridin-3-yl]-1-isopropyl-4-oxo-1,4,5,6-tetrahydro-pyrrolo[3,4-b]pyrrol-6-yl}-benzonitrile

Participants

Reaction Steps

The title compound was prepared in analogy to the procedure described for Step F1, but 2-[[5-chloro-1-(4-methoxy-benzyl)-6-oxo-1,6-dihydro-pyridin-3-ylamino]-(4-cyano-phenyl)-methyl]-1-isopropyl-1H-pyrrole-3-carboxylic acid ethyl ester (Step AF2) was used instead of 2-[(4-chloro-phenyl)-(4-hydroxy-cyclohexylamino)-methyl]-1-isopropyl-1H-pyrrole-3-carboxylic acid ethyl ester, and dimethylaluminium chloride [1184-58-3] (1M/hexanes) was used instead of trimethylaluminium. The title compound was obtained as a white solid. ESI-MS: tR=1.00 min, [M+H]+ 513/515 (LC-MS 1).

Provenance & Evidence