Nitric Acid → 5-Methoxy-2-methyl-4-nitropyridine 1-oxide

Participants

Reaction Conditions

Reaction Steps

5-Methoxy-2-methylpyridine-1-oxide [35392-66-6] (6 g, 43.1 mmol) and nitric acid (18.4 mL, 431 mmol, 1.48 g/mL) was added to acetic acid (50 mL) and the reaction was stirred at 90° C. for 6 h. The mixture was concentrated (1/4) and neutralized at 0° C. was addition of ammonium hydroxide. The mixture was extracted with EtOAc, washed with brine and water, dried (Na2SO4), filtered and concentrated. The product crystallised during concentration. ESI-MS: tR=0.50 min, [M+H]+ 185.1 (LC-MS 1).

Provenance & Evidence