HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2204336Generated: November 1, 2026
Water → 3-Bromo-5-bromomethyl-2-methoxy-pyridine
https://huagongshe.com/reaction/2204336
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Azobisisobutyronitrile | HCID 6547 | — |
| Reactant | N-bromobutanimide | HCID 67184 | — |
| Reactant | 3-Bromo-2-methoxy-5-methylpyridine | HCID 21952757 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 3-Bromo-5-bromomethyl-2-methoxy-pyridine | HCID 58539510 | — |
Reaction Steps
To a solution of 3-bromo-2-methoxy-5-methyl-pyridine (Step AM3) (3.0 g, 14.7 mmol), was added NBS (3.1 g, 17.6 mmol) and AIBN (121 mg, 0.7 mmol) and the mixture was stirred at 80° C. for 1 h. H2O and CH2Cl2 were added and the phases were separated. The organic layer was dried (MgSO4), filtered and concentrated. The crude product was purified by silica gel column chromatography (heptane/EtOAc, 95:5→0:100). tR: 1.10 min (LC-MS 1).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US09365576B2 |
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| Source dataset | uspto-grants-2016_06 |
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| ORD ID | ord-7914d3c9fc9743d8900aa49bc7b48a04 |
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| Source note | uspto-grants-2016_06 |
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