Acetonitrile → HCID 86703140, compound

Participants

Reaction Steps

A solution of 4-bromo-2-chloro-5-methoxypyridine [1020253-15-9] (1 g, 4.5 mmol) in dimethyl sulfate (1.9 mL, 19.5 mmol) was stirred at 120° C. for 16 h in a sealed tube. After cooling to rt, CH3CN and a saturated aqueous NaHCO3 solution were added and the mixture was stirred at rt over the weekend. CH2Cl2 was added and the phases were separated. The organic layer was dried (Na2SO4), filtered and concentrated to give the title compound as a white powder. ESI-MS: tR=0.57 min; [M+H]+ 218/220 (LC-MS 1).

Provenance & Evidence