反应详情

The title compound was prepared in analogy to the procedure described for Step H1, but diethylaluminium chloride (1.8M in toluene) was used instead of trimethylaluminium chloride, and methyl 5-bromo-2-(((3-chloro-2-fluorophenyl)amino)(5-chloropyridin-2-yl)methyl)-1-isopropyl-1H-pyrrole-3-carboxylate (Step BT1) was used instead of 2-[(3-chloro-4-fluoro-phenylamino)-(4-cyano-phenyl)-methyl]-1-isopropyl-1H-pyrrole-3-carboxylic acid ethyl ester to afford the title compound as a green solid. ESI-MS: tR=1.27 min, [M+H]+ 482/484/486 (LC-MS 1).

1. customThe title compound was prepared in analogy to the procedure