(2,4-Dimethoxypyrimidin-5-yl)boronic acid → HCID 72204205, compound

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Reaction Steps

The title compound was prepared in analogy to the procedure described for Example 25 but 2-bromo-5-(5-chloro-2-methyl-phenyl)-6-(4-chloro-phenyl)-1-ethyl-5,6-dihydro-1H-pyrrolo[3,4-b]pyrrol-4-one (Intermediate K) and 2,4-dimethoxypyrimidine-5-boronic acid were used instead of 2-bromo-5-(5-chloro-2-methyl-phenyl)-6-(4-chloro-phenyl)-1-isopropyl-5,6-dihydro-1H-pyrrolo[3,4-b]pyrrol-4-one and 4-methoxy-5-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-pyrimidin-2-ylamine respectively. The product was purified by flash chromatography to afford the title compound as a white solid. tR: 5.69 min (HPLC 4); ESI-MS: tR=1.30 min, [M+H]+ 523/525 (LC-MS 1); 1H-NMR (d6-DMSO, 600 MHz, 100° C.): (rotamers) 8.31 (s, 1H), 7.40 (m, 2H), 7.30 (m, 1H), 7.26 (m, 2H), 7.15-7.23 (m, 2H), 6.37 (s, 1H), 6.29 (s, 1H), 4.00 (s, 3H), 3.97 (s, 3H), 3.38/3.59 (m, 2H), 2.07 (s, 3H), 0.86 (m, 3H).

Provenance & Evidence