HCID 53630359、化合物 → HCID 72205158、化合物

関与物質

反応手順

The title compound was prepared in analogy to the procedure described for Example 25 but 2-bromo-5-(5-chloro-1-methyl-2-oxo-1,2-dihydro-pyridin-3-yl)-6-(4-chloro-phenyl)-1-isopropyl-5,6-dihydro-1H-pyrrolo[3,4-b]pyrrol-4-one (Intermediate L) and 2,4-dimethoxypyridine-5-boronic acid were used instead of 2-bromo-5-(5-chloro-2-methyl-phenyl)-6-(4-chloro-phenyl)-1-isopropyl-5,6-dihydro-1H-pyrrolo[3,4-b]pyrrol-4-one and 4-methoxy-5-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-pyrimidin-2-ylamine respectively. The title compound was obtained as a white solid. ESI-MS: tR=1.12 min, [M+H]+ 554/556/558 (LC-MS 1); 1H-NMR (d6-DMSO, 400 MHz): 8.29 (s, 1H), 7.87 (m, 1H), 7.36-7.43 (m, 3H), 7.22 (m, 2H), 6.65 (s, 1H), 6.34 (s, 1H), 3.94 (m, 1H), 3.93 (s, 3H), 3.89 (s, 3H), 3.42 (s, 3H), 1.29 (m, 3H), 0.46 (m, 3H).

情報源と証拠