Hydrochloric Acid → HCID 86703174, compound

Participants

Reaction Steps

2N Aqueous NaOH (0.906 mmol) was added to a solution of {4-[5-(3-chloro-2-fluoro-phenyl)-6-(4-cyano-phenyl)-1-isopropyl-4-oxo-1,4,5,6-tetrahydro-pyrrolo[3,4-b]pyrrol-2-yl]-5-methoxy-pyridin-2-yl}-acetic acid ethyl ester (Step 84.1) (0.227 mmol) in MeOH (0.4 mL) and THF (0.4 mL) at 0° C. After stirring for 30 min, the reaction mixture was diluted with H2O, acidified to pH 3-4 with 1N aqueous HCl and then extracted with EtOAc (2×). The combined organic layers were dried (MgSO4), filtered and concentrated. The title compound was obtained as a white solid. tR: 4.51 min (HPLC 4); ESI-MS: tR=0.99 min, [M+H]+ 559/561 (LC-MS 1).

Provenance & Evidence