Hydrochloric Acid → HCID 86703176, compound

Participants

Reaction Steps

A mixture of {5-[5-(3-chloro-2-fluoro-phenyl)-6-(4-cyano-phenyl)-1-isopropyl-4-oxo-1,4,5,6-tetrahydro-pyrrolo[3,4-b]pyrrol-2-yl]-6-methoxy-pyridin-3-yl}-acetic acid (Step 85.1) (0.054 mmol), HATU (0.161 mmol), NMM (0.215 mmol) and methylamine.HCl (0.081 mmol) in DMF (0.5 mL) at rt was stirred for 2 h. The reaction mixture was diluted with EtOAc and successively washed with a saturated aqueous solution of NaHCO3 (2×) and brine, dried (MgSO4), filtered and concentrated. The residue was purified using a silica gel column to afford the title compound as a white solid. tR: 4.96 min (HPLC 4); ESI-MS: tR=1.02 min, [M+H]+ 572/574 (LC-MS 1).

Provenance & Evidence