(2,4-Dimethoxypyrimidin-5-yl)boronic acid → HCID 86703185, compound

Participants

Reaction Steps

The title compound was prepared in analogy to the procedure described for Example 25 but 4-[2-bromo-6-(4-chloro-phenyl)-1-isopropyl-4-oxo-4,6-dihydro-1H-pyrrolo[3,4-b]pyrrol-5-yl]-piperidine-1-carboxylic acid tert-butyl ester (Intermediate AI) and 2,4-dimethoxypyrimidine-5-boronic acid were used instead of 2-bromo-5-(5-chloro-2-methyl-phenyl)-6-(4-chloro-phenyl)-1-isopropyl-5,6-dihydro-1H-pyrrolo[3,4-b]pyrrol-4-one and 4-methoxy-5-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-pyrimidin-2-ylamine respectively. The title compound was obtained as a white foam. tR=5.79 min (HPLC 4); ESI-MS: tR=1.26 min, [M+H]+ 596/598 (LC-MS 1).

Provenance & Evidence