HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Bromo-3-methoxypyridine → HCID 72205350, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Bromo-3-methoxypyridine | HCID 90364 | — |
| Reactant | (5-Cyano-2-Methoxyphenyl)Boronic Acid | HCID 23005336 | — |
| Reactant | 2-bromo-5-(5-chloro-2-methyl-phenyl)-6-(4-chloro-phenyl)-1-isopropyl-5,6-dihydro-1H-pyrrolo[3,4-b]pyrrol-4-one | HCID 86703169 | — |
| Reactant | HCID 86703194 | HCID 86703194 | — |
| Product | HCID 72205350 | HCID 72205350 | — |
Reaction Steps
The title compound was prepared in analogy to the procedure described for Example 17 but 2-bromo-3-methoxy-pyridine [24100-18-3] and 5-(5-chloro-2-methyl-phenyl)-6-(4-chloro-phenyl)-1-isopropyl-2-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-5,6-dihydro-1H-pyrrolo[3,4-b]pyrrol-4-one (Step 113.1) were used instead of 2-bromo-5-(5-chloro-2-methyl-phenyl)-6-(4-chloro-phenyl)-1-isopropyl-5,6-dihydro-1H-pyrrolo[3,4-b]pyrrol-4-one and 5-cyano-2-methoxyphenylboronic acid respectively. The title compound was obtained as a light brown solid. tR: 6.54 min (HPLC 2); ESI-MS: tR=1.27 min, [M+H]+ 506/508/510 (LC-MS 1); TLC: Rf=0.21 (98:2 CH2Cl2/MeOH).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09365576B2 |
| Source dataset | uspto-grants-2016_06 |
| ORD ID | ord-6bb1626a076c4aaca55113c1a48d9b40 |
| Source note | uspto-grants-2016_06 |