(2,4-Dimethoxypyrimidin-5-yl)boronic acid → HCID 178494056, compound

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Reaction Steps

The title compound was prepared in analogy to the procedure described for Example 17 but 4-[2-bromo-5-(trans-4-hydroxy-cyclohexyl)-1-isopropyl-4-oxo-1,4,5,6-tetrahydro-pyrrolo[3,4-b]pyrrol-6-yl]-benzonitrile (Intermediate AV) and 2,4-dimethoxypyrimidine-5-boronic acid were used instead of 2-bromo-5-(5-chloro-2-methyl-phenyl)-6-(4-chloro-phenyl)-1-isopropyl-5,6-dihydro-1H-pyrrolo[3,4-b]pyrrol-4-one and 5-cyano-2-methoxyphenylboronic acid respectively. The title compound was obtained as a white solid. tR: 5.54 min (HPLC 2); ESI-MS: tR=0.86 min, [M+H]+ 502 (LC-MS 1); TLC: Rf=0.11 (EtOAc).

Provenance & Evidence