4-Methoxy-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrimidin-2-amine → 5-(3-Chloro-2-fluorophenyl)-6-(5-chloropyridin-2-yl)-2-(2-(dimethylamino)-4-methoxypyrimidin-5-yl)-1-isopropyl-5,6-dihydropyrrolo[3,4-b]pyrrol-4(1H)-one

Participants

Reaction Steps

The title compound was prepared in analogy to the procedure described for Example 25 but 2-bromo-5-(3-chloro-2-fluorophenyl)-6-(5-chloropyridin-2-yl)-1-isopropyl-5,6-dihydropyrrolo[3,4-b]pyrrol-4(1H)-one (Intermediate BT) and 4-methoxy-N,N-dimethyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrimidin-2-amine (Intermediate W) were used instead of 2-bromo-5-(5-chloro-2-methyl-phenyl)-6-(4-chloro-phenyl)-1-isopropyl-5,6-dihydro-1H-pyrrolo[3,4-b]pyrrol-4-one and 4-methoxy-5-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-pyrimidin-2-ylamine respectively. The title compound was obtained as a brown solid. ESI-MS: tR=1.32 min, [M+H]+ 555/557/559 (LC-MS 1).

Provenance & Evidence