Sodium Hydroxide → HCID 86703243, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of methyl 2-((4-chlorophenyl)((1,5-dimethyl-6-oxo-1,6-dihydropyridin-3-yl)amino)methyl)-1-cyclopropyl-1H-pyrrole-3-carboxylate (Step 240.4) (2.2 g, 5.17 mmol) and 2M NaOH (20.7 mL, 41.3 mmol) in THF (20 mL) and MeOH (20 mL) was stirred at 70° C. for 2 hr and concentrated. The aqueous residue was acidified with 2N HCl to pH 5, and extracted twice with EtOAc. The combined organic extracts were washed with brine, dried (Na2SO4), and concentrated to afford the title compound (2 g, 89% yield) as a red foam. tR: 0.94 min (LC-MS 6); ESI-MS: 412.2 [M+H]+ (LC-MS 6).

Provenance & Evidence