HuagongsheHuagongshe Chemistry Print Report · For research reference only
Carbon tetrabromide → 4-(3-bromopropyl)-1-methyl-1H-pyrazole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Carbon tetrabromide | HCID 11205 | — |
| Reactant | Triphenylphosphine | HCID 11776 | — |
| Reactant | 3-(1-Methyl-1H-pyrazol-4-yl)propan-1-ol | HCID 18801405 | — |
| Solvent | Chloroform | HCID 6212 | — |
| Product | 4-(3-bromopropyl)-1-methyl-1H-pyrazole | HCID 45791463 | 100% |
Reaction Steps
Dissolve 3-(1-methyl-1H-pyrazol-4-yl)-propan-1-ol (0.250 g, 1.783 mmol) in dry chloroform (15 mL). Add PS-triphenylphosphine resin (1.824 g, 3.923 mmol) and carbon tetrabromide (0.650 g, 1.961 mmol). Stir at room temperature under nitrogen for 3 hr. Filter reaction over paper with DCM. Concentrate filtrate in vacuo to obtain the title preparation (0.362 g, 100% yield). GC-MS (m/z): 202/204(M+), 95.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08202873B2 |
| Source dataset | uspto-grants-2012_06 |
| ORD ID | ord-af70f8d553b64befa29b4612cb509cd2 |
| Source note | uspto-grants-2012_06 |