反应详情

温度

0 °C

Bromine (0.47 ml, 9.03 mmol) was added dropwise to a solution of methyl 2-hydroxy-4-methylbenzoate (may be prepared as described in Description 1; 1.5 g, 9.03 mmol) in chloroform (20 ml) at 0° C. The solution was stirred for 1 hour at 0° C. The reaction was quenched with saturated sodium sulphite (10 ml), then extracted with dichloromethane (2×10 ml). The combined organic layers were washed with brine (10 ml), dried (MgSO4) and the solvent removed in vacuo to yield the title compound as a white solid. 2.24 g.

1. customThe reaction was quenched with saturated sodium sulphite (10 ml)
2. extractionextracted with dichloromethane (2×10 ml)
3. washThe combined organic layers were washed with brine (10 ml)
4. dry with materialdried (MgSO4)
5. customthe solvent removed in vacuo