反应详情

NBS (0.71 g, 4.01 mmol) and benzoyl peroxide (0.07 g, 0.20 mmol) were added to a solution of methyl 2-(acetyloxy)-5-bromo-4-methylbenzoate (may be prepared as described in Description 3; 1.15 g, 4.01 mmol) in carbon tetrachloride (20 ml). The mixture was heated at reflux for 18 hours, cooled and the solvent removed in vacuo. Purification by SP4 (10-20% ethyl acetate/hexane) yielded the title compound as a pale yellow oil. 1.38 g.

1. temperatureThe mixture was heated
2. temperatureat reflux for 18 hours
3. temperaturecooled
4. customthe solvent removed in vacuo
5. customPurification by SP4 (10-20% ethyl acetate/hexane)