참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | 3,5-Dimethylpyrazole | HCID 6210 | — |
| 반응물 | Sodium hydride | HCID 24758 | — |
| 반응물 | 4-Methyloxybenzyl chloride | HCID 69993 | — |
| 용매 | Dimethylformamide | HCID 6228 | — |
| 용매 | Ammonium Chloride | HCID 25517 | — |
| 생성물 | 1-[(4-Methoxyphenyl)methyl]-3,5-dimethyl-1H-pyrazole | HCID 23377748 | 92% |
반응 단계
Dissolve 3,5-dimethylpyrazole (0.331 g, 3.44 mmol) in N,N-dimethylformamide (7 mL) and add sodium hydride (0.165 g, 4.13 mmol). After 10 min., cool to 0° C. and add 4-methoxybenzyl chloride (0.654 mL, 4.82 mmol) dropwise. Stir the mixture at 25° C. for 18 hr. then dilute with saturated ammonium chloride. Extract with ethyl acetate 3 times, dry (sodium sulfate), filter, concentrate and purify (silica gel chromatography, eluting with 40:60 hexanes:ethyl acetate), to give 1-(4-methoxybenzyl)-3,5-dimethyl-1H-pyrazole as a colorless oil (0.682 g, 92%). MS (APCI): m/z=217 [M+H].
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US08202873B2 |
|---|
| 출처 데이터셋 | uspto-grants-2012_06 |
|---|
| ORD ID | ord-79bed808bf71472e9b2f85efdd0352d9 |
|---|
| 출처 메모 | uspto-grants-2012_06 |
|---|
