反应详情

To a solution of methyl 4-bromo-2-hydroxy-5-methylbenzoate (may be prepared as described in Description 14; 1.2 g, 4.90 mmol) in pyridine (10 ml) was added acetic anhydride (2.08 ml, 22.03 mmol). The solution was stirred for one hour, then the solvent was removed in vacuo and purified by column chromatography (SiO2, 6:1 cyclohexane/ethyl acetate) to yield the title compound as a white solid. 1.28 g.

1. customthe solvent was removed in vacuo
2. custompurified by column chromatography (SiO2, 6:1 cyclohexane/ethyl acetate)