Hydrochloric Acid → HCID 66611706, compound

Participants

Reaction Steps

To a solution of methyl 4-methyl-2-(methyloxy)-5-(trifluoromethyl)benzoate (may be prepared as described in Description 44; 1.76 g, 7.09 mmol) in dichloromethane (70 ml) at 0° C. was added BBr3 (14.89 ml, 14.89 mmol). The solution was stirred for 2 hours, 2M HCl (30 ml) was added and the organic layer removed in vacuo. The residue was partitioned between water (10 ml) and ethyl acetate (20 ml). The organic layer was separated, dried (MgSO4) and the solvent removed in vacuo. The residue was purified by column chromatography (SiO2, 3:1 cyclohexane/ethyl acetate) to give the title compound as an oil. 1.37 g.

Provenance & Evidence