Benzyl Bromide → HCID 66612004, compound

Participants

Reaction Conditions

Reaction Steps

Methyl 2-hydroxy-4-(morpholinomethyl)-5-(trifluoromethyl)benzoate (may be prepared as described in Description 48; 300 mg, 0.94 mmol) was taken up in N,N-dimethylformamide (5 ml) and cesium carbonate (340 mg, 1.04 mmol) and benzyl bromide (0.16 ml, 1.31 mmol) were added. The mixture was heated at 40° C. for 18 hours. Ethyl acetate (10 ml) and water (10 ml) were added and the organic layer was separated and washed with water (2×10 ml), dried (MgSO4) and the solvent removed in vacuo. Purification by column chromatography (1:1 cyclohexane/ethyl acetate-10% 7M NH3 in methanol/dichloromethane) gave the title compound as oil. 248 mg.

Provenance & Evidence