1,2-Dichloroethane → HCID 66611389, compound

Participants

Reaction Steps

To a solution of 5-[(phenylmethyl)oxy]-4-{[(phenylmethyl)oxy]carbonyl}-2-(trifluoromethyl)benzoic acid (may be prepared as described in Description 55; 71 mg, 0.16 mmol) in N,N-dimethylformamide (4 ml) was added diisopropylethylamine (0.07 ml, 0.39 mmol), morpholine (0.03 ml, 0.29 mmol), 1-hydroxy-7-azabenzotriazole (34.2 mg, 0.25 mmol) and EDC (66.6 mg, 0.35 mmol). The mixture was stirred at room temperature for 18 hours. Ethyl acetate (10 ml) and water (10 ml) were added and the organic layer was separated, washed with water (2×10 ml), dried (MgSO4) and solvent removed in vacuo. Purification by column chromatography (SiO2, 1:1 ethyl acetate/cyclohexane) gave the title compound as a solid. 66 mg.

Provenance & Evidence