Piperidine → HCID 66611240, compound

Participants

Reaction Steps

To a solution of 5-[(phenylmethyl)oxy]-4-{[(phenylmethyl)oxy]carbonyl}-2-(trifluoromethyl)benzoic acid (may be prepared as described in Description 55; 142 mg, 0.14 mmol) in N,N-dimethylformamide (4 ml) was added diisopropylethylamine (120 ul), piperidine (0.05 ml, 0.52 mmol), 1-hydroxy-7-azabenzotriazole (60 mg), and EDC (120 mg). The solution was stirred for 18 hours. Water (10 ml) and ethyl acetate (10 ml) were added and the organic layer was separated, washed with water (2×10 ml), dried (MgSO4) and the solvent removed in vacuo. The residue was purified by column chromatography (SiO2, 1:1 ethyl acetate/cyclohexane) to yield the title compound as a gum. 170 mg.

Provenance & Evidence