1,2-Dichloroethane → HCID 66611817, compound

Participants

Reaction Steps

To a solution of 5-Bromo-4-(4-morpholinylmethyl)-2-[(phenylmethyl)oxy]benzoic acid (may be prepared as described in D7) (1 g, 2.461 mmol) in N,N-Dimethylformamide (DMF) (20 mL) was added EDC (0.849 g, 4.43 mmol), 1-hydroxy-7-azabenzotriazole (0.503 g, 3.69 mmol), 3-chloroaniline (0.504 mL, 4.92 mmol), DIPEA (0.860 mL, 4.92 mmol) and the mixture was stirred at room temperature overnight. The DMF was removed on a buchi under reduced pressure, the residue was taken up into DCM (50 ml) and washed with water (2×20 ml). The DCM was evaporated on a buchi under reduced pressure and the residue was purified using the Companion eluting with 0-50% ethyl acetate/cyclohexane to give the title compound as pale yellow oil which solidified on standing. Yield: 400 mg

Provenance & Evidence