Hydrochloric Acid → HCID 66611525, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of benzyl 2-(benzyloxy)-5-chloro-4-(4-methylpiperazine-1-carbonyl)benzoate (may be prepared as described in D75) (400 mg, 0.837 mmol) in tetrahydrofuran (THF) (5.00 mL) were added lithium hydroxide (63.4 mg, 2.65 mmol) and water (1.5 mL). The mixture was stirred at 40° C. for 2 hours. After cooling, 2M hydrochloric acid (1.386 mL, 2.77 mmol) was added. The solvent was removed in vacuo to give the title product as a crude solid (324 mg, assuming 100% yield).

Provenance & Evidence