1,2-Dichloroethane → HCID 66612041, compound

Participants

Reaction Steps

Diisopropylethylamine (72.2 μl, 0.414 mmol), HOBT (38.0 mg, 0.248 mmol), 3-aminopyridine (29.2 mg, 0.310 mmol) and EDC (79 mg, 0.414 mmol) To a solution of 5-bromo-4-(4-morpholinylmethyl)-2-[(phenylmethyl)oxy]benzoic acid (may be prepared as described in Description 7; 84 mg, 0.207 mmol) in N,N-dimethylformamide was added. The reaction was stirred over the weekend, then the solvent was removed in vacuo. Purification by MDAP gave the title compound as a white solid. 30 mg.

Provenance & Evidence