1,2-Dichloroethane → HCID 66612041, compound

Participants

Reaction Steps

Diisopropylethylamine (132 μl, 0.76 mmol), HOBT (69.7 mg, 0.46 mmol), 3-aminopyridine (53.5 mg, 0.57 mmol) and EDC (145 mg, 0.76 mmol) were added to a solution of 5-bromo-4-(4-morpholinylmethyl)-2-[(phenylmethyl)oxy]benzoic acid (may be prepared as described in Description 7; 154 mg, 0.38 mmol) in N,N-dimethylformamide. The reaction was stirred overnight, then the solvent was removed in vacuo. Purification by MDAP yielded the title compound as a white solid. 42 mg.

Provenance & Evidence