Sodium Carbonate → HCID 66611992, compound

Participants

Reaction Conditions

Reaction Steps

Na2CO3 (0.23 ml, 0.23 mmol) and palladium tetrakis (7.91 mg, 6.84 μmol) were added to 5-bromo-4-(4-morpholinylmethyl)-2-[(phenylmethyl)oxy]-N-3-pyridinylbenzamide (may be prepared as described in Example 2; 55 mg, 0.11 mmol) and (1-methyl-1H-pyrazol-4-yl)boronic acid (17.23 mg, 0.137 mmol) in 1,2-dimethoxyethane (3 ml). The mixture was heated at 120° C. in a microwave for one hour and the solvent was removed in vacuo. The residue was purified by MDAP to yield the title compound as a white solid. 27 mg.

Provenance & Evidence