HuagongsheHuagongshe Chemistry Print Report · For research reference only
Diisopropylethylamine → 5-Bromo-4-methyl-2-[(phenylmethyl)oxy]-N-4-pyridazinyl benzamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | 4-Aminopyridazine | HCID 298492 | — |
| Reactant | Methanaminium, N-((dimethylamino)(3H-1,2,3-triazolo(4,5-b)pyridin-3-yloxy)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1) | HCID 9886157 | — |
| Reactant | 5-Bromo-4-methyl-2-[(phenylmethyl)oxy]benzoic acid | HCID 66611218 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 5-Bromo-4-methyl-2-[(phenylmethyl)oxy]-N-4-pyridazinyl benzamide | HCID 66611786 | — |
Reaction Steps
4-Pyridazinamine (207 mg, 2.18 mmol), diisopropylethylamine (0.52 ml, 2.97 mmol) and HATU (904 mg, 2.38 mmol) were added to a solution of 5-bromo-4-methyl-2-[(phenylmethyl)oxy]benzoic acid (may be prepared as described in Description 9; 636 mg, 1.98 mmol) in N,N-dimethylformamide (10 ml). The mixture was stirred for 2 hours, after 10 minutes a solid had crashed out of solution. The solid was filtered and washed with ethyl acetate (10 ml) to yield the title compound. 475 mg.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09365551B2 |
| Source dataset | uspto-grants-2016_06 |
| ORD ID | ord-f57f22d7bf5d4fe48454b4deb5aeed5f |
| Source note | uspto-grants-2016_06 |