HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-Aminopyridine → 5-Bromo-4-methyl-2-[(phenylmethyl)oxy]-N-3-pyridinylbenzamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-Aminopyridine | HCID 10009 | — |
| Reactant | Methanaminium, N-((dimethylamino)(3H-1,2,3-triazolo(4,5-b)pyridin-3-yloxy)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1) | HCID 9886157 | — |
| Reactant | 5-Bromo-4-methyl-2-[(phenylmethyl)oxy]benzoic acid | HCID 66611218 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 5-Bromo-4-methyl-2-[(phenylmethyl)oxy]-N-3-pyridinylbenzamide | HCID 66611237 | — |
Reaction Steps
3-Aminopyridine (193 mg, 2.06 mmol), and HATU (852 mg, 2.24 mmol) were added to a solution of 5-bromo-4-methyl-2-[(phenylmethyl)oxy]benzoic acid (may be prepared as described in Description 9; 600 mg, 1.87 mmol) in N,N-dimethylformamide (10 ml). The reaction was stirred overnight and the solid was filtered. Solvent was removed in vacuo and water was added. The solid was filtered and washed with ethyl acetate (10 ml) to give a white solid. The products were combined to yield the title compound as an off white solid. 508 mg.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09365551B2 |
| Source dataset | uspto-grants-2016_06 |
| ORD ID | ord-4f3439be070648d38a4584de37fec8c5 |
| Source note | uspto-grants-2016_06 |