Sodium Carbonate → HCID 66614654, compound

Participants

Reaction Conditions

Reaction Steps

Sodium carbonate (0.30 ml, 0.30 mmol) was added to 4-bromo-5-methyl-2-[(phenylmethyl)oxy]-N-3-pyridinylbenzamide (may be prepared as described in Example 9; 59 mg, 0.15 mmol), 1-methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole (37.1 mg, 0.18 mmol) and palladium tetrakis (10.30 mg, 8.91 μmol) in 1,2-dimethoxyethane (3 ml). The mixture was heated in a microwave at 120° C. for 1 hour, the solvent was removed in vacuo and the solid purified by MDAP to yield the title compound as a white solid. 30 mg.

Provenance & Evidence