Sodium Carbonate → HCID 66611948, compound

Participants

Reaction Conditions

Reaction Steps

Sodium carbonate (0.32 ml, 0.32 mmol) was added to 4-bromo-5-methyl-2-[(phenylmethyl)oxy]-N-4-pyridazinylbenzamide (may be prepared as described in Example 10; 64 mg, 0.16 mmol), 1-methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole (40.1 mg, 0.19 mmol) and Pd(Ph3P)4 (11.14 mg, 9.64 μmol) in 1,2-dimethoxyethane (3 ml). The mixture was heated in a microwave at 120° C. for 1 hour, the solvent was removed in vacuo and the solid triturated with DMSO/methanol (1:1, 1 ml) to yield the title compound as a white solid. 9 mg.

Provenance & Evidence