反应详情

Dissolve 2,4-pentanedione (0.81 mL, 7.85 mmol) and pyrimidin-2-yl-hydrazine (1.037 g, 9.42 mmol) in acetic acid (10 mL). Stir the mixture for 69 hr. at room temperature then concentrate. Dilute the residue with saturated aqueous sodium bicarbonate, extract 3 times with DCM, dry (sodium sulfate), filter and concentrate to give 2-(3,5-dimethylpyrazol-1-yl)-pyrimidine as a white solid (1.333 g, 97%). MS (ES): m/z=175 [M+H]+.

1. concentrationat room temperature then concentrate
2. additionDilute the residue with saturated aqueous sodium bicarbonate
3. extractionextract 3 times with DCM
4. dry with materialdry (sodium sulfate)
5. filtrationfilter
6. concentrationconcentrate