HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-Aminopyridine → HCID 66614676, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-Aminopyridine | HCID 10009 | — |
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | Methanaminium, N-((dimethylamino)(3H-1,2,3-triazolo(4,5-b)pyridin-3-yloxy)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1) | HCID 9886157 | — |
| Reactant | HCID 66611075 | HCID 66611075 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 66614676 | HCID 66614676 | — |
Reaction Steps
To a solution of 2-{[(4-fluorophenyl)methyl]oxy}-5-(1-methyl-1H-pyrazol-4-yl)-4-(4-morpholinylcarbonyl)benzoic acid (may be prepared as described in Description 29; 12 mg, 0.02 mmol) in N,N-dimethylformamide (4 ml), was added diisopropylethylamine (4.15 μL, 0.02 mmol), 3-aminopyridine (2.23 mg, 0.02 mmol) and HATU (9.03 mg, 0.02 mmol). The reaction stirred for 18 hours, then the solvent was removed in vacuo. The residue was purified by MDAP to yield the title compound as a gum. 4.8 mg.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09365551B2 |
| Source dataset | uspto-grants-2016_06 |
| ORD ID | ord-8f078a01528746a8bf078c1d8edab002 |
| Source note | uspto-grants-2016_06 |