1,2-Dichloroethane → HCID 66614683, compound

Participants

Reaction Steps

To a solution of 5-(1-methyl-1H-pyrazol-4-yl)-2-[(phenylmethyl)oxy]-4-(1-piperidinylcarbonyl)benzoic acid (may be prepared as described in Description 38; 80 mg, 0.19 mmol) in N,N-dimethylformamide (5 ml) was added diisopropylethylamine (0.13 ml, 0.76 mmol), 3-aminopyridine (32.3 mg, 0.34 mmol), 1-hydroxy-7-azabenzotriazole (46.7 mg, 0.34 mmol) and EDC (91 mg, 0.48 mmol). The solution was stirred for 3 hours. The solvent was removed in vacuo and the residue purified by MDAP to give the title compound as a white solid. 33 mg.

Provenance & Evidence