1,2-Dichloroethane → HCID 66611787, compound

Participants

Reaction Steps

To a solution of 4-(4-morpholinylmethyl)-2-[(phenylmethyl)oxy]-5-(trifluoromethyl)benzoic acid (may be prepared as described in Description 50; 120 mg, 0.30 mmol) in N,N-dimethylformamide (5 ml) was added diisopropylethylamine (0.11 ml, 0.61 mmol), 3-aminopyridine (42.8 mg, 0.46 mmol), 1-hydroxy-7-azabenzotriazole (53.7 mg, 0.40 mmol) and EDC (116 mg, 0.61 mmol). The solution was stirred for 2 hours, then the solvent was removed in vacuo. The yellow residue was purified by MDAP to give the title compound as a white solid. 106 mg.

Provenance & Evidence