1,2-Dichloroethane → HCID 66611133, compound

Participants

Reaction Steps

To a solution of 2-((4-fluorobenzyl)oxy)-5-(1-methyl-1H-pyrazol-4-yl)-4-(morpholine-4-carbonyl)benzoic acid (150 mg, 0.341 mmol) (may be prepared as described in description D68) in N,N-Dimethylformamide (DMF) (3 mL), was added EDC (98 mg, 0.512 mmol), 1-hydroxy-7-azabenzotriazole (55.8 mg, 0.410 mmol), DIPEA (0.119 mL, 0.683 mmol) 3-chloroaniline (0.054 mL, 0.512 mmol) and the mixture was stirred at room temperature overnight. The organics were evaporated and the residue was purified using the MDAP to give the title compound. Yield: 58 mg

Provenance & Evidence