1,4-Dioxane hydrochloride → HCID 131735798, compound

Participants

Reaction Steps

To a solution of 2-(benzyloxy)-N-(3-chlorophenyl)-5-(1-methyl-1H-pyrazol-4-yl)-4-(morpholinomethyl)benzamide (43 mg, 0.083 mmol) (may be prepared as described in example 49) in Methanol (3 mL) was added an excess of 1,4-dioxane HCl solution (1 mL, 11.69 mmol) at room temperature. The mixture was stirred at room temperature for 1 hour and evaporated on a buchi under reduced pressure to give a pale yellow solid. The solid was triturated with ether (5 ml) and the solid filtered off to give the title compounds as a pale yellow solid. Yield: 44 mg

Provenance & Evidence