1,2-Dichloroethane → HCID 66611053, compound

Participants

Reaction Steps

To a solution of 2-(benzyloxy)-4-(morpholinomethyl)-5-(trifluoromethyl)benzoic acid (may be prepared as described in description 50, 270 mg, 0.683 mmol) in N,N-Dimethylformamide (DMF) (5 mL) was added DIPEA (0.239 mL, 1.366 mmol), 3-chloroaniline (72.0 μl, 0.683 mmol), 1-hydroxy-7-azabenzotriazole (112 mg, 0.819 mmol) and EDC (262 mg, 1.366 mmol). The solution was stirred for 3 hours then partitioned between EtOAc (20 ml) and water (15 ml). The organic layer was separated, washed further with water (2×20 ml), dried (MgSO4) and the solvent removed. Purification by column (SiO2, Isolute, 3:1-1:1 Cyclohexane/EtOAc) gave the product as a white solid. 205 mg.

Provenance & Evidence