1,2-Dichloroethane → HCID 66611767, compound

Participants

Reaction Steps

To a solution of 2-(benzyloxy)-5-chloro-4-(4-methylpiperazine-1-carbonyl)benzoic acid (may be prepared as described in D 76) (108 mg, 0.278 mmol) in N,N-dimethylformamide (DMF) (5 mL) was added DIPEA (0.97 ml, 0.555 mmol), 3-aminopyridine (39.2 mg, 0.417 mmol) and 1-hydroxy-7-azabenzotriazole (HOAt) (45 mg, 0333 mmol) and EDC (96 mg, 0.5 mmol). The solution was stirred overnight. The solvent was removed in vacuo and the residue was purified by MDAP (tartan, High pH, 25 minute run) to give a white solid (33 mg, 9% yield).

Provenance & Evidence