HuagongsheHuagongshe Chemistry Print Report · For research reference only
N-bromobutanimide → Methyl 3-Amino-6-bromopyrazine-2-carboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | N-bromobutanimide | HCID 67184 | — |
| Reactant | Methyl 3-aminopyrazinecarboxylate | HCID 72669 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | Methyl 3-Amino-6-bromopyrazine-2-carboxylate | HCID 227251 | 92.3% |
Reaction Steps
A mixture of methyl 3-aminopyrazine-2-carboxylate (8.35 g, 54.53 mmol) and N-bromo-succinimide (9.705 g, 54.53 mmol) was stirred in MeCN (100 mL) at room temp overnight. The resultant precipitate was filtered, washed with MeCN and dried to give the desired product as a yellow solid (11.68 g, 92% Yield)
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09365557B2 |
| Source dataset | uspto-grants-2016_06 |
| ORD ID | ord-40e2dcdfe1bc46e5afadcad1f4e21468 |
| Source note | uspto-grants-2016_06 |