HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2204782Generated: November 1, 2026
Hydrochloric Acid → 3-Amino-6-(4-methylsulfonylphenyl)pyrazine-2-carboxylic acid
https://huagongshe.com/reaction/2204782
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Water | HCID 962 | — |
| Reactant | Lithium Hydroxide | HCID 3939 | — |
| Reactant | Methyl 3-amino-6-(4-(methylsulfonyl)phenyl)pyrazine-2-carboxylate | HCID 51000410 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 3-Amino-6-(4-methylsulfonylphenyl)pyrazine-2-carboxylic acid | HCID 51000409 | 99.4% |
Reaction Steps
A mixture of methyl 3-amino-6-(4-(methylsulfonyl)phenyl)pyrazine-2-carboxylate (3.50 g, 11.39 mmol) and LiOH (1.364 g, 56.95 mmol) was dissolved in Methanol (14 mL) and water (14 ml) and allowed to heat at 90° C. for 2 hours. The reaction mixture was allowed to cool and neutralized with 1M HCl. The resultant precipitate was collected by filtration to afford the pure product as a yellow solid (3.32 g, 99% Yield). MS (ES+) 293
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US09365557B2 |
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| Source dataset | uspto-grants-2016_06 |
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| ORD ID | ord-3ac73ff856f64260ae34bda478af2bd1 |
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| Source note | uspto-grants-2016_06 |
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