HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2204793Generated: November 1, 2026
3-amino-N'-(benzoyloxy)-6-bromopyrazine-2-carboximidamide → 5-Bromo-3-(5-phenyl-1,2,4-oxadiazol-3-yl)pyrazin-2-ylamine
https://huagongshe.com/reaction/2204793
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | 3-amino-N'-(benzoyloxy)-6-bromopyrazine-2-carboximidamide | HCID 72295113 | — |
| Solvent | Water | HCID 962 | — |
| Product | 5-Bromo-3-(5-phenyl-1,2,4-oxadiazol-3-yl)pyrazin-2-ylamine | HCID 59472205 | 87% |
Reaction Steps
A mixture of 3-amino-N′-(benzoyloxy)-6-bromopyrazine-2-carboximidamide (575 mg, 1.711 mmol) and polyphosphonic acid (2.300 mL) was heated at 70° C. for 3.5 hours. The resultant solution was diluted with water (20 mL), quenched with NaHCO3 and the resultant product isolated by filtration (475 mg, 87% Yield) as a fawn solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US09365557B2 |
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| Source dataset | uspto-grants-2016_06 |
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| ORD ID | ord-ec46766d1c3a4dec8cc0ed82cb2bf3dc |
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| Source note | uspto-grants-2016_06 |
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